How do you write a good essay
Sunday, August 23, 2020
The role of nuclear energy in the field of medicine
Atomic vitality is a kind of vitality which is discharged by a response called as atomic response. There are two fundamental kinds of atomic responses, one is called parting and the other one is combination: In Fission response it discharges an atomic vitality when a solitary overwhelming core seperates into two littler ones, making vitality be discharged . The most widely recognized component used to experience atomic parting is uranium since uranium has numerous positive properties. Uranium cores can be handily part by applying neutrons at them. The parting response is utilized to make heat for creating steam, which is then utilized by a turbine to produce power. be that as it may, if in a combination response a two single cores joins together to shape another core which is heavier. This response happens just under extremely hot conditions. Atomic combination is utilized to produce a ton of vitality as light, hear and radiation. This vitality bolsters life on our planet and it was the main vitality early humanity utilized. 1) ââ¬Å"What Is Nuclear Energy.â⬠What Is Nuclear Energy. N.p., n.d. Web. 22 Aug. 2012. <http://whatisnuclearenergy.net/>. 2) ââ¬Å"Nuclear Energy.â⬠ThinkQuest. Prophet Foundation, n.d. Web. 22 Aug. 2012. http://library.thinkquest.org/3471/nuclear_energy.html Picture 1: 1) Picture 2: ââ¬Å"Free Energy: Nuclear Fusion in the Quran.â⬠Pakalert Press. N.p., n.d. Web. 22 Aug. 2012. <http://www.pakalertpress.com/2010/09/24/atomic combination in-the-quran/>. Researchers have found that atomic vitality can be utilized in rewarding different illnesses, for example, malignant growth, coronary illness, endocrine, gastrointestinal and different anomalies discovered inside the body. Atomic vitality gives a decent arrangement in rewarding certain sicknesses influencing individuals in todayââ¬â¢s world. In the field of Cardiopulmonary. Atomic vitality is utilized in filtering and imagining blood stream and furthermore heart work. In rewarding malignant growth sicknesses, for example, Melanoma and bosom disease, Nuclear vitality can have their lymph mondes found first before doing the medical procedure. It can likewise see if there are respiratory issues and blood stream in lungs. Another major significant utilization of Nuclear vitality is for the treatment of different malignant growths, for example, Melanoma and bosom disease. Patients having Melanoma and bosom malignant growth can have their lymph hubs discovered first before doing the medical procedure, thyroid disease and tumors that spread to the bones are likewise relieved by utilizing Nuclear vitality. In other analytic utilization of atomic vitality, Nuclear vitality is utilized to assess tumors, joint inflammation, breaks and infenction of bones. Finding the region where there is a disease, recognizing issues causing gallbladder irritation and seeping into the gut can be dealt with utilizing atomic vitality. It can likewise be utilized to research cerebrum anomalies, for example, loss of memory, seizures and variations from the norm in blood stream. ââ¬Å"General Nuclear Medicine.â⬠Nuclear Medicine, General. N.p., n.d. Web. 26 Aug. 2012. <http://www.radiologyinfo.org/en/info.cfm?pg=gennuclear>. ââ¬Å"How Is Nuclear Energy Used in Medicine?â⬠Yahoo! Patron Network. N.p., n.d. Web. 26 Aug. 2012. <http://voices.yahoo.com/how-atomic vitality utilized medication 5892958.html>. The viability of utilizing atomic vitality to tackle sicknesses is successful in light of the fact that for eg; if a patient having malignant growth experiences medical procedure, before doing the medical procedure specialists need to find the particular zone where the disease are situated to do this X-beam tomography or (CT) checks work by utilizing atomic tracers to emmit gamma beams once the beams are inside the body, unique cameras can get the produced gamma beams and show to the photograph of the organ or the part where the malignant growth is to the specialist. This causes the specialists to effectively treat the patient. Another further developed innovation called a Positron Emission Tomography (PET) isused in deciding patients with heart conditions, issues in the cerebrum and malignant growth, first positron-radiating radionuclides are infused into the patients body and afterward they incline toward the organ and they start to rapidly rot. They emmit a positron and an electron from within the patients body a two unmistakable gamma beams which the PET outputs and structures a picture. The photograph encourages specialists to find where the issue is, this is further developed than CT checks. Looking at strategies like CT sweeps and PET outputs to different techniques like Endoscopic ultrasound and others to figure out where the disease is to techniques like mind filter, the strategy for CT examines are probably going to be progressively hazardous and may hurt the patient in light of the fact that in CT checks they use differentiate operators which are concoction substances that are presented to the human body when they are running the test. Differentiation specialists like Iodine is the difference operator which is the most ordinarily utilized complexity specialist can make hypersensitive responses a few patients which incorporates a rash, a warm sensation or even in a most dire outcome imaginable trouble to inhale regularly. Additionally in CT filters it includes patients to get presented to ionizing radiation which is known to cause disease. This turns into an issue for individuals who need different outputs and furthermore for kids since youngsters are more touchy to radiation than to grown-ups. So despite the fact that CT outputs can help specialists to find where the infection is they arenââ¬â¢t that solid and can be unsafe too in the event that they are not utilized appropriately. ââ¬Å"Symptoms and Diagnosis.â⬠Symptoms and Diagnosis. N.p., n.d. Web. 26 Aug. 2012. <http://www.braintumor.org/patients-family-companions/about-mind tumors/side effects and-diagnosis.html>. Cioffi, Rebecca. ââ¬Å"How Does Nuclear Medicine Actually Kill Cancer Cells?â⬠EHow. Request Media, 30 Apr. 2009. Web. 26 Aug. 2012. <http://www.ehow.com/how-does_4966096_medicine-really murder malignancy cells.html>. Social: The utilization of CT outputs to perform examines inside the body for the area of sicknesses inside the body can be valuable and can assist with rewarding the patients. In any case, CT checks are cutting edge gadgets and are over the top expensive which are just accessible in evolved nations, for less fortunate nations like in Africa have no innovation and cash to get CT scanners and need to depend on elective answers for fix their maladies, Which now and again give off base outcomes. Condition: CT scanners need atomic vitality to create the picture inside the patientââ¬â¢s body. Atomic vitality is one of the worldââ¬â¢s most effective vitality maker and power. This helps the general public without a doubt. In any case, atomic vitality additionally can cause an extraordinary arrangement measure of harm to the earth. On the off chance that a CT scanner has a gamma beam spill out it can make ozone depleting substance emanations rise and damage the earth. Yields and drinking water presented to gamma beam can cause lung tumor and thyroid disease whenever devoured, Animals and marine life will be influenced by it additionally, so individuals who are liable for upkeep of the scanners must keep up the machine well or not there will be an extraordinary outcome to confront. From making this exposition I came to think about the extraordinary utilization of atomic force in the field of medication, They can identify malignant growth, tumor and drain inside a personââ¬â¢s body and help specialists in rewarding them. In any case, I likewise discovered that there is a confinement to this innovation since certain individuals have unfavorably susceptible responses from atomic vitality and whenever presented an excessive amount to a personââ¬â¢s body as opposed to rewarding the infection it can cause one, so we should be dependable utilizing this solid vitality.
Friday, August 21, 2020
To What Extent Did The X Factor Alter The Distribution of Popular Coursework
What exactly Extent Did The X Factor Alter The Distribution of Popular Music - Coursework Example In the course of the most recent decade, unscripted TV dramas have been the most mainstream programs on TV. This marvel isn't limited to the United States or the UK, however is an all inclusive wonder. There is by all accounts a connection between's the rise of unscripted television as a power, and the all inclusive take-up of the web (Butje, 2005). The X-Factor gives an intriguing contextual analysis identifying with the effect of unscripted television on the way of life of individuals over the world. The show began in the UK and afterward spread to different nations. There are different establishments of the show in various nations over the world. The objective of this paper is to inspect the effect of the X-Factor on the circulation of well known music. The best records identifying with the show originate from the UK since this is the place the show has been running for a very long time. The other huge market for the show is the United States. This paper will concentrate on the ef fect of the show on dissemination of music in the UK. ... In the two shows, the members experience a progression of tryouts before arriving at the screening stages where the finalists come up for concentrated preparing and rivalry during the show. The fundamental thought behind the naming of the program and its entire significance is the revelation of the ââ¬Å"X factorâ⬠that makes a performer tick. The show targets finding this immaterial and incredible factor in the competitors. b. Creation Stages The show advances through five phases. In the principal stage, the makers do the essential tryouts and gives competitors who will meet senior makers a ââ¬Å"golden ticketâ⬠. The senior makers further recognize hopefuls who continue to the subsequent stage. At the subsequent stage, the appointed authorities tryout the members and group them into three â⬠the great ones who continue to the following stage, the terrible ones who are poor at singing, and the peculiar ones. This last class alludes to the individuals who hang out here and there that is neither acceptable nor terrible. The fruitful hopefuls experience further handling at the ââ¬Å"boot campâ⬠and afterward at the appointed authorities houses where the adjudicators get a chance to coach them. The individuals who pass these two phases effectively continue to the last stage that frames the principle part of the TV appear. It is toward the finish of this last stage the show picks its victor. c. Key Players The most compelling individual in the X-Factor show is Simon Cowell. Cowell was a piece of the group that delivered Pop Idol in America. He left the Pop Idol creation group so as to begin the X-Factor in the UK. Cowell is as of now part of the debut group of judges in X-Factor USA. The other key characters in X-Factor are the appointed authorities. Each season has a lot of judges to take the appear on the other side. This makes them persuasive
Wednesday, July 8, 2020
Social Media Research Paper - 275 Words
Social Media (Research Paper Sample) Content: Social MediaName:Institution: The use of social media has greatly been enhanced by the increased internet use across the globe in the last one decade. It has impacted society both positively and negatively and has become quite necessary in facilitating interactions among individuals. Some of the commonly used social media sites include Facebook and YouTube. People from different countries across the world have been able to interact and share their cultural beliefs and practices. As a result, social media has resulted to cultural homogenization whereby people have acquired similar principles and practices making the world quite uniform. It has also provided a platform for people to learn new things and embrace cultures that are acceptable in a global scope. With the continuous technological advancements, there have been improvements in social media functioning. It has become possible for society to regulate the content people of certain ages are able to view. Security levels have been boosted through the encryption of different sites. Social media is therefore essential and its continued use is important as the modern society aligns itself to technological innovations which can potentially transform interactions for the better. YouTube YouTube is one of the worlds phenomenal video sharing sites. According to Alleyne (2008), the idea to invent a video sharing platform was initiated in February 2005 by Clad Hurley and Steve Chen who were colleagues and had found it impossible to upload their videos to the internet compared to pictures. With Chen being a specialist in computer science and Hurley good in fine art, designing the new website was quite smooth. They worked closely with their friend, Jawad Karim whom they were colleagues at PayPal and had the first video clip posted in YouTube on April 23, 2005. After seeing their pursuits pay at last, the website was made open for societal members to view it and use it to share videos. Despite having to overcome various financial constraints, the founders great work was acknowledged by various internet firms such as Google. After attempting to have YouTube remain independent in vain due to the lack of computing and communication capabilities, an acquisition deal with Google was signed in October 2006 with Chen and Hurley getting Google shares worth thousands of million dollars. Karim had left YouTube after its inception meaning that his colleagues were the best suited to enjoy its success (Alleyne, 2008). YouTube has had various advantages as well as disadvantages to its users during its close to a decade period of use. The advantages involve the fact that YouTube has made it possible for people to earn money. For instance, people find it easy to open Google Adsense accounts through which they may have some money credited into their accounts depending on the quality and number of videos they upload thereby attracting many individuals into the site. It also provides an opportunity f or individuals from different parts of the globe to attract other organizations to post ads on their video pages so that they may market their activities and through the internet. YouTube has played a huge role in making people famous and at the same enlighten individuals from different countries on activities that happen in other societies. By posting amazing video clips, people attract millions of viewers thereby boosting the popularity of individuals as well as their unique abilities. YouTube also has the advantage of being a social networking site owing to the fact that it makes it likely for people meet others who have similar interests or have them connected so that they may continuously share ideas. People do not have to make any payments so that their videos may be made available for people to view them in the site and this makes it convenient (Sondagar, 2013).The disadvantages associated with YouTube include the high cost of purchasing and maintaining the equipments require d to take quality videos. Moreover, maintaining skilled personnel to take the videos is expensive considering that payments by the site are made depending on the ads made on the pages basing on views. The high competition posed by the emergence of new web video platforms has also been disadvantageous to may YouTube users who find it difficult to attain the desired popularity. The extent at which people upload low quality content in the site has also reduced the urge by individuals to use the site thereby posing further problems (Christian, 2011). Facebook Facebook was founded in 2004 by Mark Zuckerberg who had come up with different social networking websites for his fellow students at Harvard University. Its original name was The Facebook which had been derived from the sheets distributed to students in his schools as he tried to urge may people to sign up. Within a few months, Facebook spread to other universities in US before it became Facebook.com in 2005 after acquiring the ad dress for $200,000. Facebook use among outside schools began in September 2006 whereby people only needed email addresses to sign up freely and socialize with their friends. Its features have continued to advance and this has led to Facebook attracting over 30 million users making it the largest social networking site (Phillips, 2007). Facebook has a number of advantages. Firstly, it provides an opportunity for people to receive the latest information in a more convenient way. As a result, people in areas where they do not have access to televisions or radios get the chance to know what is happening across the globe. Secondly, Facebook has provided a platform for people to make new friends and connect with old pals who they would not have otherwise traced their whereabouts. Thirdly, the site has been helpful to businesses in that it has made advertising easy and cheap. With features such as advertising and fan pages, Facebook has provided a stage for businesspeople to extend their consumer base and provide timely information whenever changes are made (HubPages Inc, 2013). On the other hand, Faceb... Social Media Research Paper - 275 Words Social Media (Research Paper Sample) Content: Social MediaName:Institution: The use of social media has greatly been enhanced by the increased internet use across the globe in the last one decade. It has impacted society both positively and negatively and has become quite necessary in facilitating interactions among individuals. Some of the commonly used social media sites include Facebook and YouTube. People from different countries across the world have been able to interact and share their cultural beliefs and practices. As a result, social media has resulted to cultural homogenization whereby people have acquired similar principles and practices making the world quite uniform. It has also provided a platform for people to learn new things and embrace cultures that are acceptable in a global scope. With the continuous technological advancements, there have been improvements in social media functioning. It has become possible for society to regulate the content people of certain ages are able to view. Security levels have been boosted through the encryption of different sites. Social media is therefore essential and its continued use is important as the modern society aligns itself to technological innovations which can potentially transform interactions for the better. YouTube YouTube is one of the worlds phenomenal video sharing sites. According to Alleyne (2008), the idea to invent a video sharing platform was initiated in February 2005 by Clad Hurley and Steve Chen who were colleagues and had found it impossible to upload their videos to the internet compared to pictures. With Chen being a specialist in computer science and Hurley good in fine art, designing the new website was quite smooth. They worked closely with their friend, Jawad Karim whom they were colleagues at PayPal and had the first video clip posted in YouTube on April 23, 2005. After seeing their pursuits pay at last, the website was made open for societal members to view it and use it to share videos. Despite having to overcome various financial constraints, the founders great work was acknowledged by various internet firms such as Google. After attempting to have YouTube remain independent in vain due to the lack of computing and communication capabilities, an acquisition deal with Google was signed in October 2006 with Chen and Hurley getting Google shares worth thousands of million dollars. Karim had left YouTube after its inception meaning that his colleagues were the best suited to enjoy its success (Alleyne, 2008). YouTube has had various advantages as well as disadvantages to its users during its close to a decade period of use. The advantages involve the fact that YouTube has made it possible for people to earn money. For instance, people find it easy to open Google Adsense accounts through which they may have some money credited into their accounts depending on the quality and number of videos they upload thereby attracting many individuals into the site. It also provides an opportunity f or individuals from different parts of the globe to attract other organizations to post ads on their video pages so that they may market their activities and through the internet. YouTube has played a huge role in making people famous and at the same enlighten individuals from different countries on activities that happen in other societies. By posting amazing video clips, people attract millions of viewers thereby boosting the popularity of individuals as well as their unique abilities. YouTube also has the advantage of being a social networking site owing to the fact that it makes it likely for people meet others who have similar interests or have them connected so that they may continuously share ideas. People do not have to make any payments so that their videos may be made available for people to view them in the site and this makes it convenient (Sondagar, 2013).The disadvantages associated with YouTube include the high cost of purchasing and maintaining the equipments require d to take quality videos. Moreover, maintaining skilled personnel to take the videos is expensive considering that payments by the site are made depending on the ads made on the pages basing on views. The high competition posed by the emergence of new web video platforms has also been disadvantageous to may YouTube users who find it difficult to attain the desired popularity. The extent at which people upload low quality content in the site has also reduced the urge by individuals to use the site thereby posing further problems (Christian, 2011). Facebook Facebook was founded in 2004 by Mark Zuckerberg who had come up with different social networking websites for his fellow students at Harvard University. Its original name was The Facebook which had been derived from the sheets distributed to students in his schools as he tried to urge may people to sign up. Within a few months, Facebook spread to other universities in US before it became Facebook.com in 2005 after acquiring the ad dress for $200,000. Facebook use among outside schools began in September 2006 whereby people only needed email addresses to sign up freely and socialize with their friends. Its features have continued to advance and this has led to Facebook attracting over 30 million users making it the largest social networking site (Phillips, 2007). Facebook has a number of advantages. Firstly, it provides an opportunity for people to receive the latest information in a more convenient way. As a result, people in areas where they do not have access to televisions or radios get the chance to know what is happening across the globe. Secondly, Facebook has provided a platform for people to make new friends and connect with old pals who they would not have otherwise traced their whereabouts. Thirdly, the site has been helpful to businesses in that it has made advertising easy and cheap. With features such as advertising and fan pages, Facebook has provided a stage for businesspeople to extend their consumer base and provide timely information whenever changes are made (HubPages Inc, 2013). On the other hand, Faceb...
Tuesday, May 19, 2020
Apush Terms Chapter 1 a People and a Nation Essay examples
Chapter 1 Lady of Cofitachequi: Cofitachequi was a paramount chiefdom encountered by the Hernando de Soto Expedition in South Carolina. They encountered the Chiefdom of Cofitachequi in April of 1540, at the Mulberry Site, a large platform mound at the junction of Pine Tree Creek and the Wateree River, near present-day Camden. Paleo-Indians: First Americans. Nomadic hunters of game and gatherers of wild plants, they spread throughout North and South America, probably moving as bands composed of extended families. The Mayas: Developed approximately two thousand years ago. On the Yucatan Peninsula, in todayââ¬â¢s eastern Mexico, the Mayas built urban centers containing tall pyramids and temples. They studied astronomy and created andâ⬠¦show more contentâ⬠¦They also engaged in ritual combat, known as flowery wars, to obtain further sacrificial victims. The war godââ¬â¢s taste for blood was not easily quenched. In the Aztec year Ten Rabbit (1502), at the coronation of Motecuhzoma II (the Spaniards could not pronounce his name correctly, so they called him Montezuma), thousands of people were sacrificed by having their still-beating hearts torn from their bodies. The Aztecs believed that they lived in the age of the Fifth Sun. Four times previously, they wrote, the earth and all the people who lived on it had been destroyed. They predicted that their own world would end in earthquakes and hunger. In the Aztec year Thirteen Flint, volcanoes erupted, sickness and hunger spread, wild be asts attacked children, and an eclipse of the sun darkened the sky. In time, the Aztecs learned that Thirteen Flint was called, by Europeans, 1492. Huitzilopochtli: A war god represented by an eagle. Tenochtitlan: Capital of the Aztecs and the center of a rigidly stratified society composed of hereditary classes of warriors, merchants, priests, common folk, and slaves. Sexual Division of Labor: Societies that relied primarily on hunting large animals, such as deer and buffalo, assigned that task to men, allotting food preparation and clothing production to women. Before such nomadic bands acquired horses from theShow MoreRelatedAnalysis Of The Je Quan D. Sailes Irving1166 Words à |à 5 Pages Jeââ¬â¢Quan D. Sailes-Irving APUSH Summer Assignment Chapter 1: Chapter 1 focused on introducing two politicians that were about to have a duel on July 11, 1804. Aaron Burr was the third vice president of the United States and the vice president during Thomas Jeffersonââ¬â¢s term. Alexander Hamilton was a founding father of the United States and apart of the federalist party. Both Hamilton and Burr were each other s political rival and would insult one another until they arranged a duel to endRead MoreThesis Statements1159 Words à |à 5 PagesJacob Dearing APUSH 2/20/13 Thesis assignment 1. The American city was changed drastically in the first half of the 20th century with the beginnings of the industrial revolution and the ongoing flow of foreigners into an already crowded United States. 2. Many men around the time of the 20th century had parts in the progressive era reform and were influential in politics and majorly through social conditions. 3. Progressive era reforms were not that prominent in the lateRead MoreEssay on Howard Zinn Answer Guide1869 Words à |à 8 PagesReid Thorpe August 3, 2010 APUSH Mr. Sayers Zinn; Chapter 1: 1.) Howard Zinnââ¬â¢s main purpose for writing A Peopleââ¬â¢s History of the United States is to give history in an un-biased manner. For example, he says that he will not glorify any movement and denounce any ââ¬Ëbad guyââ¬â¢ in history; he will give information as it should be given. Fairly. 2.) His thesis for the first eleven pages is to describe past events as they happened. Regarding Columbus, Zinn wouldnââ¬â¢t glorify him as a hero, becauseRead MoreBoyer Dbq Teacher Guide10764 Words à |à 44 Pagesdocument applications. Here, the documents are discussed in order to facilitate easy teacher reference. Students, of course, must link documents to their individual essay structures; they should not simply discuss them in the order they appear. DBQ 1: European Colonization of North America, to 1660 The supportive structure and small number of documents chosen for this question are intended to make this a good starting point for teaching students to write DBQ essays. The three criteria offered forRead MoreThe Jacksonian Era3389 Words à |à 14 PagesNAME: Brandon Longo ________/55 APUSH Mr. Broggy Chapter 10 The Jacksonian Era, 1824-1845 Directions Answer all of the following learning objectives in writing (hand-written only please). These are to be answered in full sentences not bullet points. Think of this as writing paragraphs for each of these objectives. If additional space is needed, use the back of the page. Make sure that you are including facts, names, specific dates, and of
Wednesday, May 6, 2020
A Data Driven Decision Making Platform Essay - 842 Words
In this dissertation, a data-driven decision making platform is developed focusing on individuals at high risk of getting breast and ovarian cancers due to their BRCA gene mutations. First a likelihood estimation model is built based on a gradient boosting model. This model is capable of identifying individuals at high risk of having BRCA mutations based on their family and personal history of cancers. Then, a Markov decision process (MDP) model is formulated to help BRCA mutation carriers and their health providers to find effective intervention actions (based on cost or quality-adjusted life years) to prevent breast and ovarian cancers. Finally, a robust MDP (RMDP) model is presented to study the sensitivity of MDP optimal strategies under uncertainty. In what follows, I present a summary of findings in Chapters 2, 3, and 4 of this dissertation. In Chapter 2, four machine learning classifiers are used to find the likelihood of having BRCA mutation based on detailed personal and family history of cancer information. The data used for validation of the models emerges from a recent nation-wide survey study (ABOUT) of those who requested BRCA genetic testing through one of the commercial health insurance companies in the United States. This is the first study evaluating existing well-known BRCA risk estimation models using data on general population in the United States. The models considered were gradient boosting model (GBM), random forest, support vector machines, andShow MoreRelatedAccenture : Strategic Decision Making1648 Words à |à 7 Pagesimpact typically will yield an invaluable prizeââ¬âgreater and more credible clarity around ROI. 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Mitochondria free essay sample
Mitochondria are the cells power producers. They convert energy into forms that are usable by the cell. Located in the cytoplasm, they are the sites of cellular respiration which ultimately generates fuel for the cells activities. Mitochondria are also involved in other cell processes such as cell division and growth, as well as cell death. They convert oxygen and nutrients into adenosine triphosphate (ATP). ATP is the chemical energy currency of the cell that powers the cells metabolic activities. This process is called aerobic respiration and is the reason animals breathe oxygen. Mitochondria are bounded by a double membrane. Each of these membranes is a phospholipid bilayer with embedded proteins. The outermost membrane is smooth while the inner membrane has many folds. These folds are called cristae. The folds enhance the productivity of cellular respiration by increasing the available surface area. The double membranes divide the mitochondrion into two distinct parts: the intermembrane space and the mitochondrial matrix. We will write a custom essay sample on Mitochondria or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page The intermembrane space is the narrow part between the two membranes while the mitochondrial matrix is the part enclosed by the innermost membrane. Several of the steps in cellular respiration occur in the matrix due to its high concentration of enzymes. Mitochondria are semi-autonomous in that they are only partially dependent on the cell to replicate and grow. They have their own DNA, ribosomes and can make their own proteins. Similar to bacteria, mitochondria have circular DNA and replicate by a reproductive process called fission. The inner membrane selects over what materials are allowed through it and it is known that active transport mechanisms involving translocase enzymes are responsible for the movement of ADP and ATP across it. Mitochondria use respiration to brake down high energy molecules such as sugars and store that energy as ATP (produced from ADP a phosphate) The raw materials used to generate ATP are the foods that we eat, or tissues within the body that are broken down in a process called catabolism. The breaking down of food into simpler molecules such as carbohydrates, fats, and protein is called metabolism. These molecules are then transferred into the mitochondria, where further processing occurs. The reactions within the mitochondria produce specific molecules that can have their electrical charges separated within the inner mitochondrial membrane. These charged molecules are processed within the five electron transport chain complexes to finally combine with oxygen to make ATP. The process of the charged substances combining with oxygen is called oxidation, while the chemical reaction making ATP is called phosphorylation. The overall process is called oxidative phosphorylation. The product produced by this process is ATP. Using Oxygen to Release Energy Mitochondria are used in cellular respiration. The matrix is filled with water and proteins (enzymes). Those proteins take food molecules and combine them with oxygen. The mitochondria are the only place in the cell where oxygen can be combined with the food molecules. After the oxygen is added, the material can be digested. They are working organelles that keep the cell full of energy. On the ethical implications of mitochondrial DNA analysis: Mitochondrial DNA analysis is a somewhat different type of DNA analysis compared to other techniques used today. It generally works well on samples that are unable to be analysed through numerous other techniques. So is There a Risk From Complete mtDNA Sequencing ? Yes, and the risk from having a complete mtDNA sequencing begins when a person first thinks about ordering the test as for the first time it is possible to have a test performed for genealogical purposes that can actually affect the persons well being. Before agreeing to mtDNA sequencing it is important to consider just how one might be affected by the results. Fortunately, for about 90-95% of people the results will not show any mutations of medical significance. But this means that about 5-10% of people can expect results that show a significant mutationââ¬âfor example, as is shown in Table 12 where the subject has the significant mutation at A4295G. Because of the random nature of mutations, it is impossible to predict in advance who might receive such results. The figure of 5-10% is the present authors estimate from studying the mutations found in all of the 2,500 published complete mtDNA sequences. It is possible that some of the sequences have been published by the researchers because of the mutations that the sequences containââ¬âthis would make the 5-10% figure too high. But against this, mutations associated with medical conditions continue to be identifiedââ¬âthis would raise the figure. The author suggests the figure of 5-10% when mtDNA is sequenced for genealogical purposes. Besides the person themselves worrying, should they be telling other people that they are going to be tested? And, if so, who should be told? Close relatives and doctors, perhaps. But probably not at this early stage an employer or health insurance company. It is difficult to judge how important pre-testing anxietymight become, but for some people, fear of adverse results will quite properly stop them from undergoing the testing. However, if mtDNA sequencing is undertaken it becomes important to determine just how significant the results might be. The results for the Haplogroup H9 person shown earlier, demonstrate that test results can suggest there are no adverse medical mutations, and in such a case there would not appear to be any reason for concern. For the great majority of tests the outcome will be similar. But what about a case such as that for the Haplogroup K1 person (shown earlier)? Here the results suggest that the subject has a mutation linked to a significant heart condition. In such a situation it would seem important to convey things in their proper proportions and give the person the most complete understanding of the situation as is possible. In most instances it would be sufficient to explain that most mtDNA mutations do not cause the disease with which they are associated, but rather explain why the particular condition might arise. Just at present it would seem that most genealogical testing companies are not involving themselves in analysing their results for any medical implications; and it is uncertain how such service might be provided. But what is clear is that counselling people who have been been found to have important mutations will not be easy, and perhaps will lead to as many unanswerable questions being posed, as questions for which answers can be given. But it is not just the person who receives test results indicating possible medical problems who is affectedââ¬âother family members will also have obvious concerns. A mother who receives adverse test results will certainly worry about the health of her children; and a younger person will have concerns about their siblings and mother. Medically significant mtDNA mutations should not be ignored, in the authors view, and their possible significance should be discussed with the familys medical practitioners. Overall, the discovery of potentially harmful mtDNA mutations may have many unexpected and undesirable consequences. Given the role of mitochondria as the cells powerhouse, there may be some leakage of the high-energy electrons in the respiratory chain to form reactive oxygen species. This can result in significantoxidative stress in the mitochondria with high mutation rates of mitochondrial DNA. A vicious cycle is thought to occur, as oxidative stress leads to mitochondrial DNA mutations, which can lead to enzymatic abnormalities and further oxidative stress. A number of changes occur to mitochondria during the aging process. Tissues from elderly patients show a decrease in enzymatic activity of the proteins of the respiratory chain. Large deletions in the mitochondrial genome can lead to high levels of oxidative stress and neuronal death in Parkinsons disease. Hypothesized links between aging and oxidative stress are not new and were proposed over 50 years ago however, there is much debate over whether mitochondrial changes are causes of aging or merely characteristics of aging. One notable study in mice demonstrated shortened lifespan but no increase in reactive oxygen species despite increasing mitochondrial DNA mutations, suggesting that mitochondrial DNA mutations can cause lifespan shortening by other mechanisms. As a result, the exact relationships between mitochondria, oxidative stress, and aging have not yet been settled.
Wednesday, April 22, 2020
Picture This You Are Going To Travel Over One Thousand Essays
Picture this: You are going to travel over one thousand miles across Alaska---by car? by train? by plane? NO!! You are travelling by dogsled - your only companions on this journey will be eleven to fourteen of the most honest, loyal and strong dogs that you can find. For over six grueling months, you and your carefully selected dogs have been training, and now it is up to you and your canine companions. For sledders (or "mushers") this is a dream come true because they are about to start the Iditarod - a name possibly derived from the Indian word "Ingalik" meaning"distant place". Only half of the starting team of dogs will finish. Those with the strongest heart and the will to go on against overwhelming odds will complete the race. The Iditarod is a dogsled race that takes place in Alaska every year. It goes from Anchorage (Alaska's largest city) to Nome, stretching over 1,000 miles of icy, snow-covered ground. The Iditarod was begun in the 1960's when people tried to restore tradition to Alaska. It was first run to commemorate a trip that took place in 1925 to deliver medicine to Nome. The race has two routes, the Northern and the Southern. In even-numbered years, the Northern route is used and in odd-numbered years, the Southern route is used. The Iditarod is the hardest and toughest dogsled race there is. Sometimes the mushers get so tired, they hallucinate. What makes the race so demanding? Three features: time, temperature and distance. The temperature in Alaska is so cold that it can reach up to 40 degrees below zero during the running of the race. Because it gets so cold, the mushers have to wear several layers of clothing. One of the major sponsors (Timberland) has made specially-designed clothes to keep them warm, including sleeping bags, snowshores, special long underwear, boots for wet and dry surfaces, water resistant climbing suits, and mittens made out of beaver skin. Other equipment includes dog "booties" for the dogs' feet, and a six foot long 28 pound tobaggan. One tobaggan, made by North Star is called the "Ferrari " of dogsleds. More than one sled is used. As the land gets flatter and icier, a new sled with flat runners is used. This sled is easier for the dogs to pull on the icy surface. For training, the dogs are split up into two teams for three days of workout and one day of rest. It is critical that the dogs be able to maintain their pace even when they are exhausted. The dogs get a few days off before the "big day". Sometimes accidents can happen. For example, when training, Bruce Johnsen, Canada's top musher, plunged through the ice of a frozen lake where he and his eight dog team died. The mushers and their team can get attacked by a moose, like when Susan Butcher got attacked by a near 500 pound moose, killing two of her dogs and injuring one. Mushers are now starting to carry weapons to defend themselves from moose. While the team is on the trail, the mushers drive the team for six to eight hours at a time, then they take a break and feed the dogs (beaver and horsemeat, plus beef). They also rest or sleep. During the first couple of miles out of Anchorage, the dogs go about 14 miles an hour, but after that they slow down slightly to 11 or 12 miles per hour. The starting positions are drawn based upon when a person enters. To enter the race, you must complete a 200 mile race. When the race starts, each team has a one day supply of food. Also on the trail are 25 checkpoints that each team must check in at. At some checkpoints, veterinarians check the dogs. Some mushers pick up fresh dogs and leave the tired ones at the checkpoint. For some mushers, the prize money at the end of the race is enough to keep them going ($50,000 to the winner, and $150,000 split among the next ten finishers). But for others it is an honor just to finish the trail. IDITAROD FACTS: Mushers rely on voice commands. Among them are: Mush! - Let's go! Gee! - Turn right! Haw! - Turn Left! Whoa! - Stop! SUPPLIES: - Snowhoes, sleeping bag. - Eight booties per dog, plus a restraint to carry an injured or sick dog on the sled. - Two pounds of food per dog. - Three dog drop chains (for dogs left at checkpoints) - Hand ax, head lamp, matches or lighter, plus emergency - lighting equipment CHECKLIST: Gangline: heavy nylon line that harnesses the dogs' strength to the back of the sled. Tugline:
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